ChloroquineV1, Main, Exploration, bibRecord, 003D46

Metabolism of chloroquine and hydroxychloroquine in albino and pigmented rats

Identifieur interne : 003D46 ( Main/Exploration ); précédent : 003D45; suivant : 003D47

Metabolism of chloroquine and hydroxychloroquine in albino and pigmented rats

Auteurs : Evan W. Mcchesney [États-Unis] ; William F. Banks Jr. [États-Unis] ; David J. Sullivan [États-Unis]

Source :

Toxicology and Applied Pharmacology [ 0041-008X ] ; 1965.

RBID : ISTEX:AB883E2FF10453412B1A9DF17A5EEA4EFD3A4574

Descripteurs français

KwdFr :
- Albinisme (métabolisme), Animaux, Chloroquine (métabolisme), Femelle, Foie (métabolisme), Hydroxychloroquine (métabolisme), Muscles (métabolisme), Myocarde (métabolisme), Mâle, Oeil (métabolisme), Pigmentation, Poumon (métabolisme), Rate (métabolisme), Rats, Rein (métabolisme), Sang.
MESH :
- métabolisme : Albinisme, Chloroquine, Foie, Hydroxychloroquine, Muscles, Myocarde, Oeil, Poumon, Rate, Rein.
- Animaux, Femelle, Mâle, Pigmentation, Rats, Sang.

English descriptors

KwdEn :
- Albinism (metabolism), Animals, Blood, Chloroquine (metabolism), Eye (metabolism), Female, Hydroxychloroquine (metabolism), Kidney (metabolism), Liver (metabolism), Lung (metabolism), Male, Muscles (metabolism), Myocardium (metabolism), Pigmentation, Rats, Spleen (metabolism).
MESH :
- chemical , metabolism : Chloroquine, Hydroxychloroquine.
- metabolism : Albinism, Eye, Kidney, Liver, Lung, Muscles, Myocardium, Spleen.
Teeft :
- Albino, Albino rats, Animals, Antimalarial, Antimalarial metabolism, Bernstein, Blood, Body weight, Buffer wash, Chloroquine, Collagen diseases, Daily dosage, Daily dose, Doses number, Equal amount, Female, First month, Histopathologic examination, Hooded, Hooded rats, Hydroxychloroquine, Liver dosages, Male, Medication, Metabolism, Method extracts, Ocular, Ocular concentration, Ocular histopathology, Ocular tissues, Other tissues, Pigment epithelium, Pigmentation, Rat, Rats, Retinopathy, Slow release, Spleen, Standard error, Third month, Third months, Tissue concentration, Tissue concentrations, Tissue distribution, Total amount, Trade name, Unchanged drug, Winthrop laboratories.

Abstract

Abstract: The administration of chloroquine or hydroxychloroquine to albino and pigmented (hooded) rats at a daily dosage of 40 mg/kg produces a rapid rise in tissue concentrations of the drugs during the first month of medication, but comparatively little further rise when the medications are continued for two additional months. The mean tissue concentration of chloroquine at 1 month is about 100 mg/kg, compared to about 30 mg/kg for hydroxychloroquine. However, rats degrade the latter compound more extensively, so that their total mean tissue content of 4-aminoquinoline bases is greater than 30 mg/kg at that time. The order of increasing tissue concentration for both drugs is almost invariably: muscle, eye, heart, kidney, liver, lung, and spleen. In the pigmented rats, the order is: muscle, heart, kidney, liver, lung, spleen, and eye. When medication is discontinued, the concentrations of both drugs in the tissues decrease very rapidly, except in the eyes of the pigmented rats. Long-continued exposure of the eyes of the pigmented rats to high concentrations (approaching 0.1%) of chloroquine or hydroxychloroquine and their degradation products does not produce any detectable ocular histopathology.

Url:

https://api.istex.fr/ark:/67375/6H6-ZBMMG2S7-C/fulltext.pdf

DOI: 10.1016/0041-008X(65)90050-5

Affiliations:

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<term>Blood</term>
<term>Chloroquine (metabolism)</term>
<term>Eye (metabolism)</term>
<term>Female</term>
<term>Hydroxychloroquine (metabolism)</term>
<term>Kidney (metabolism)</term>
<term>Liver (metabolism)</term>
<term>Lung (metabolism)</term>
<term>Male</term>
<term>Muscles (metabolism)</term>
<term>Myocardium (metabolism)</term>
<term>Pigmentation</term>
<term>Rats</term>
<term>Spleen (metabolism)</term>
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<term>Animaux</term>
<term>Chloroquine (métabolisme)</term>
<term>Femelle</term>
<term>Foie (métabolisme)</term>
<term>Hydroxychloroquine (métabolisme)</term>
<term>Muscles (métabolisme)</term>
<term>Myocarde (métabolisme)</term>
<term>Mâle</term>
<term>Oeil (métabolisme)</term>
<term>Pigmentation</term>
<term>Poumon (métabolisme)</term>
<term>Rate (métabolisme)</term>
<term>Rats</term>
<term>Rein (métabolisme)</term>
<term>Sang</term>
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<term>Hydroxychloroquine</term>
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<term>Kidney</term>
<term>Liver</term>
<term>Lung</term>
<term>Muscles</term>
<term>Myocardium</term>
<term>Spleen</term>
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<term>Chloroquine</term>
<term>Foie</term>
<term>Hydroxychloroquine</term>
<term>Muscles</term>
<term>Myocarde</term>
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<term>Rein</term>
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<term>Blood</term>
<term>Body weight</term>
<term>Buffer wash</term>
<term>Chloroquine</term>
<term>Collagen diseases</term>
<term>Daily dosage</term>
<term>Daily dose</term>
<term>Doses number</term>
<term>Equal amount</term>
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<term>Rats</term>
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<term>Slow release</term>
<term>Spleen</term>
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<term>Third months</term>
<term>Tissue concentration</term>
<term>Tissue concentrations</term>
<term>Tissue distribution</term>
<term>Total amount</term>
<term>Trade name</term>
<term>Unchanged drug</term>
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<front><div type="abstract" xml:lang="en">Abstract: The administration of chloroquine or hydroxychloroquine to albino and pigmented (hooded) rats at a daily dosage of 40 mg/kg produces a rapid rise in tissue concentrations of the drugs during the first month of medication, but comparatively little further rise when the medications are continued for two additional months. The mean tissue concentration of chloroquine at 1 month is about 100 mg/kg, compared to about 30 mg/kg for hydroxychloroquine. However, rats degrade the latter compound more extensively, so that their total mean tissue content of 4-aminoquinoline bases is greater than 30 mg/kg at that time. The order of increasing tissue concentration for both drugs is almost invariably: muscle, eye, heart, kidney, liver, lung, and spleen. In the pigmented rats, the order is: muscle, heart, kidney, liver, lung, spleen, and eye. When medication is discontinued, the concentrations of both drugs in the tissues decrease very rapidly, except in the eyes of the pigmented rats. Long-continued exposure of the eyes of the pigmented rats to high concentrations (approaching 0.1%) of chloroquine or hydroxychloroquine and their degradation products does not produce any detectable ocular histopathology.</div>
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Serveur d'exploration Chloroquine

Metabolism of chloroquine and hydroxychloroquine in albino and pigmented rats

Metabolism of chloroquine and hydroxychloroquine in albino and pigmented rats

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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